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L.WangZ.et al (2017)

The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory

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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

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This may indicate inadequate treatment intensity or an alternative neurological condition